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Effect of cisplatin and etoposide at various concentrations in H520 and SK-MES-1 cell lines with overexpression of ARRB1(+) or knockdown of ARRB1(−). The cell viability was evaluated by (A) MTT assay and (B) colony formation assay. ARRB1 overexpression enhanced the sensitivity of tumor cells to chemotherapy at lower concentrations and ARRB1-knockdown increased resistance to chemotherapy.
