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. 2016 Nov 1;14(6):5171–5179. doi: 10.3892/mmr.2016.5913

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Association between the expression NRF2, KEAP1, NQO-1 and HO-1 and clinicopathological features in advanced laryngeal cancer tissues. (A) The expression levels of NRF2, KEAP1, NQO-1 and HO-1 in the patients with age <62 years old are not significantly higher than the patients with age ≥62 (P=0.157, 134, 574 and 0.200, respectively). (B) The expression levels of these proteins are not obviously associated with lymph node metastasis (P=0.867, 0.926, 0.957 and 0.266 respectively). (C) There are no significant differences in the expression levels of NRF2, KEAP1, NQO-1 and HO-1 between the patients with diagnosed tumor stage III and IV (P=0.761, 0.972, 0.667 and 0.621 respectively). (D) Tumor size has no significant impact on the expression levels of NRF2, KEAP1, NQO-1 and HO-1 (P=0.531, 0.809, 0.315 and 0.828 respectively). Data are expressed as the mean values of patient characteristics. N+, lymph node metastasis; N0, no lymph node metastasis; NRF2, nuclear factor (erythroid-derived 2)-like 2; KEAP1, kelch-like ECH-associated protein-1; NQO-1, quinone oxidoreductase-1; HO-1, heme oxygenase-1.