Table I.
Chr | Cytoband | AvgCGHLR | Gene names |
---|---|---|---|
1 | p22.2-p22.1 | 3.37 | TGFBR3 |
3.39 | |||
2 | q32.2 | 3.25 | COL5A2 |
2.95 | |||
12 | q24.11 | 2.82 | SART3, ISCU, TMEM119, |
2 | SELPLG, CORO1C, SSH1 | ||
13 | q32.1 | 2.51 | UGCGL2 |
1.51 | |||
19 | q13.43 | 3.64 | CHMP2A, UBE2M, |
1.98 | LOC100131691, MZF1 | ||
21 | q22.3 | 3.94 | C2CD2, ZNF295 |
2.02 | |||
22 | q12.1 | 2.26 | PITPNB |
2.21 | |||
X | q28 | 1.46 | ARHGAP4, ARD1A, |
1.35 | RENBP, HCFC1 |
TGFBR3: decreased expression of this receptor has been observed in various cancers (5–7). COL5A2: colorectal carcinogenesis is associated with stromal expression of COL11A1 and COL5A2 (20). SART3: an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy (www.genecards.org). CORO1C: silencing of CORO1C gene expression inhibited cancer cell proliferation, migration and invasion (10). SSH1: plays a role in cancer cell motility and invasion. Amplification reported in testicular germ cell tumor (21,22). CHMP2A: diseases associated include osteosarcoma, and adenocarcinoma (www.genecards.org). MZF1: significantly induces tumor formation and liver metastasis, furthermore, MZF1 expression is positively correlated with Axl expression in resected colorectal cancer. Diseases associated also include bladder TCC (www.genecards.org) (23).