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Secretion of (A) matrix metalloproteinase (MMP)-9 and (B) nuclear factor-κB (NF-κB) p65 activity in peripheral blood mononuclear cells (PBMCs) from healthy donors and melanoma cases following treatment with recombinant human osteopontin (rhOPN). The levels of both (A) MMP-9 and (B) NF-κB p65 activity were higher in patients with melanoma than in the controls. *P<0.05 compared to the rhOPN-treated cells. OD, optical density.
