Table II.
Mean concentration of OPN and MMP-9, and MMP-9a anctivity in 148 cases of menaloma according to clinopathological characteristics.
| OPN | MMP-9 | MMP-9 activity | ||||
|---|---|---|---|---|---|---|
| BRAFWT | BRAFMUT | BRAFWT | BRAFMUT | BRAFWT | BRAFMUT | |
| Overall | 142.7 | 148.5 | 128.0 | 154.1d | 2.93 | 4.21d |
| Hystological type | ||||||
| Superficial spreading | 134.1 | 131.4 | 121.0 | 133.3 | 2.39 | 3.33c |
| Nodular | 150.7 | 162.1 | 134.5 | 170.6d | 3.44 | 4.91c |
| Sentinel lymph node | ||||||
| Negative | 131.8 | 132.8 | 118.3 | 133.1b | 2.56 | 3.12c |
| Positive | 171.5 | 168.4 | 153.6 | 180.6c | 3.90 | 5.59b |
| Breslow thickness | ||||||
| ≤2 mm | 124.9 | 116.8 | 114.6 | 119.8 | 2.42 | 2.81 |
| >2 mm | 177.5 | 167.3b | 154.1 | 174.4d | 3.93 | 5.05b |
| Clark's level | ||||||
| 2–3 | 137.2 | 135.6 | 124.1 | 142.1c | 2.77 | 3.69c |
| 4–5 | 221.5 | 186.2b | 183.5 | 189.0 | 5.30 | 5.74 |
| Ulceration | ||||||
| No | 129.5 | 135.4 | 116.4 | 136.8b | 2.60 | 3.74c |
| Yes | 161.9 | 163.3 | 144.8 | 174.8d | 3.40 | 4.87c |
a
Differences were examined by ANOVA, accounting for gender and age. Significance levels are indicated as follows:
b
<0.05
c
<0.01
d
<0.001. OPN, osteopontin; MMP-9, matrix metalloproteinase-9.