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. 2016 Dec 5;15(1):97–102. doi: 10.3892/mmr.2016.5980

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effects of BBR on STAT3 activation. (A) Representative histograms illustrate the expression of p-STAT3 in anti-CD3/28-stimulated CD4⁺ T cells in a HC treated with DMSO or BBR. (B) The number of p-STAT3⁺ cells expressed as a percentage of CD4⁺ T cells from HC following exposure to BBR or DMSO. (C) The expression of p-STAT3 expressed as the mean fluorescence intensity (MFI) in CD4⁺ T cells from HCs following exposure to BBR or DMSO. Data are presented as the mean ± standard deviation. BBR, berberine; p-STAT3, phosphorylated signal transducer and activator of transcription 3; DMSO, dimethyl sulfoxide; HC, healthy control.