Skip to main content
. 2016 Nov 1;14(6):4983–4990. doi: 10.3892/mmr.2016.5916

Figure 3.

Figure 3.

TSIIA suppresses NF-κB activation and downregulates inflammatory factors, adhesion molecules and MCP-1. (A) Expression levels of macrophage markers, galectin-3 and CD68, in descending arteries of apoE−/− mice was detected by western blotting (P=0.0157 and P=0.0274). (B) Expression levels of VCAM-1, ICAM-1 and MCP-1 in the descending arteries were detected using western blotting (P=0.0218, 0.0223 and 0.0018). (C) NF-κB activation in the descending arteries was analyzed by measuring NF-κB, p-NF-κB, IκBα, and p-IκBα levels (P=0.2743, 0.0234, 0.00428 and 0.034). Data represent the mean ± standard error (n=4). *P<0.05, **P<0.01 vs. con. Con, control; TSIIA, Tanshinone II A; VCAM-1, vascular cell adhesion molecule; ICAM-1, intercellular adhesion molecule; MCP-1, monocyte chemoattractant protein-1; p-, phosphorylated; NF-κB, nuclear factor-κB; IκBα, NF-κB inhibitor α.