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. 2017 Mar 13;8:14664. doi: 10.1038/ncomms14664

Figure 5. Model for the contribution of Sfrp5-expressing cardiac precursors to heart development.

Figure 5

Upper panels show the expression area of Sfrp5 (orange) and Islet1 (light green) and the distribution of descendants of Sfrp5-expressing (red) and Islet1-expressing (green) cells at E7.5 (right) and E9.5 (left). The lower panel shows the lineage contribution to each part of the heart. Mesodermal cells, which transiently express Mesp1, may become cardiac precursor cells expressing Islet1 (light green) or Sfrp5 (orange). A portion of Sfrp5-expressing cells later begins to express Islet1 (purple). Transient Islet1-expressing cells that do not express Sfrp5 contribute to the RV, OFT and atrium (green), and cells that express Sfrp5 contribute to the OFT and atrium (purple) but not to the RV. Cells that transiently express Sfrp5 contribute to the LV, atrium and OFT (orange), and cells that continuously express Sfrp5 form the SV.