Figure 5.

The inhibitory effect of C. sativum on the apoptotic cells production in regions of the hippocampus (CA1, CA2, CA3, and DG) in rats after induction of seizure by PTZ. TUNEL positive cells in CA1, CA2, CA3, and DG regions of PTZ group were significantly more than control groups. Administration of 50 mg/kg coriander extract significantly declined the mean number of TUNEL positive cells only in CA1 region. By using of 100 and 200 mg/kg of C. sativum, apoptotic cells number considerably was decreased in all regions. ⁺ p<0.05, ⁺⁺ p<0.01 and ⁺⁺⁺ p<0.001 as compared to PTZ group. ^**p<0.01 and ^***p<0.001 as compared to control group.