. 2017 Mar 17;7:44449. doi: 10.1038/srep44449

Table 2. Effect of (a) analogues of resveratrol (compound 1) and (b) (hydroxyphenyl)ethylphenols on inhibition (IC₅₀) of the epoxide hydrolase (LTB₄ generation) and aminopeptidase (PGP degradation) activities of LTA₄H as described in Materials and methods.

Cmpd. No.	R₁	R₂	R₃	Epoxide Hydrolase IC₅₀ ± SEM (μM)			Aminopeptidase IC₅₀ ± SEM (μM)

1	OH	OH	OH	32.2 ± 5.9			>100
2^a	OH	OH	OH	14.3 ± 2.1			85.3 ± 33.9
3	OMe	OMe	OMe	41.2 ± 5.5			68.8 ± 9.9
4	OCOMe	OCOMe	OCOMe	38.6 ± 5.9			>100
5	OMe	OH	OH	3.9 ± 0.4			99.5 ± 22.6

Cmpd. No.	R₁	R₂	R₃	R₄	R₅	Epoxide Hydrolase IC₅₀ ± SEM (μM)		Aminopeptidase IC₅₀ ± SEM (μM)
6	OMe	OH	H	H	OH	6.4 ± 0.7		>100
7	OEt	OH	H	H	OH	3.2 ± 0.7		>100
8	OMe	OH	H	OH	H	1.7 ± 0.25		>100
9	OMe	OH	OH	H	H	0.50 ± 0.04		>100

IC₅₀ curves were generated from 3 technical replicates at each concentration of test compound and at least 2 biological replicates. Results depicted as mean ± SEM.

^aZ-isomer.

Table 2. Effect of (a) analogues of resveratrol (compound 1) and (b) (hydroxyphenyl)ethylphenols on inhibition (IC50) of the epoxide hydrolase (LTB4 generation) and aminopeptidase (PGP degradation) activities of LTA4H as described in Materials and methods.

Table 2. Effect of (a) analogues of resveratrol (compound 1) and (b) (hydroxyphenyl)ethylphenols on inhibition (IC₅₀) of the epoxide hydrolase (LTB₄ generation) and aminopeptidase (PGP degradation) activities of LTA₄H as described in Materials and methods.