. 2017 Mar 17;7:44449. doi: 10.1038/srep44449

Table 3. Effect of isoflavones on inhibition (IC₅₀) of the epoxide hydrolase (LTB₄ generation) and aminopeptidase (PGP degradation) activities of LTA₄H as described in Materials and methods.

Cmpd. No.	R₁	R₂	R₃	Epoxide Hydrolase IC₅₀ ± SEM (μM)	Aminopeptidase IC₅₀ ± SEM (μM)

10				34.24 ± 4.7	>100
11	OH	OH	H	15.0 ± 2.3	>100
12	OH	OH	OH	7.3 ± 0.8	62.7 ± 13.3
13	H	OH	H	48.2 ± 14.6	>100
14	OH	O-CH₂-O		20.6 ± 2.4	20.6 ± 3.3
15	OH	Me	OH	1.2 ± 0.21	69.2 ± 10.9

IC₅₀ curves were generated from 3 technical replicates at each concentration of test compound and at least 2 biological replicates. Results depicted as mean ± SEM.

Table 3. Effect of isoflavones on inhibition (IC50) of the epoxide hydrolase (LTB4 generation) and aminopeptidase (PGP degradation) activities of LTA4H as described in Materials and methods.

Table 3. Effect of isoflavones on inhibition (IC₅₀) of the epoxide hydrolase (LTB₄ generation) and aminopeptidase (PGP degradation) activities of LTA₄H as described in Materials and methods.