Figure 1.
A high folic acid diet increases the total tumour volume and the number of tumours in PyMT transgenic mice. Polyoma virus middle T transgenic female mice received a standard rodent diet (with 2 mg folic acid per kg added, N=11) or a high folic acid diet (with 10 mg folic acid per kg added, N=10) from day 23 to day 62 where they were killed. From each mouse, 10 breast tissues were dissected and the volume was measured. (A) The average tumour volume per mouse is shown for each group. Student's t-test: ***P<0.0001. (B) The average number of tumours from each mouse with a volume above 100 and 200 mm3 were counted and the average number per mouse is shown for each group. Student's t-test: *P=0.01, ***P=0.0003.