Table 2. Significantly dysregulated miRNAs in the plasma and serum of patients with CRC as compared with controls.
miRNA | Expression | Area under the curve (AUC) | Sensitivity | Specificity | Study |
---|---|---|---|---|---|
Single miRNA | |||||
miR-17-3p | Upregulated | 0.717 | 64% | 70% | Ng et al, 2009 |
0.781 | —a | — | Li et al, 2015 | ||
miR-18a | Upregulated | 0.804 | 73.1% | 79.1% | Zhang et al, 2013 |
— | — | — | Brunet Vega et al, 2013 | ||
miR-19a-3p | Upregulated | 0.849 | — | — | Zheng et al, 2014 |
miR-20a | Upregulated | 0.590 | 46% | 73.42% | Chen et al, 2015 |
miR-21 | Upregulated | 0.910 | 90% | 90% | Kanaan et al, 2012 |
0.850 | 87.5% | 74.4% | Wang and Zhang, 2012 | ||
0.802 | 65% | 85% | Liu et al, 2013 | ||
0.927 | 82.8% | 90.6% | Toiyama et al, 2013 | ||
0.870 | 77% | 78% | Basati et al, 2014 | ||
0.877 | 76.2% | 93.2% | Du et al, 2014 | ||
0.647 | — | — | Zanutto et al, 2014 | ||
miR-29a | Upregulated | 0.844 | 69% | 89.1% | Huang et al, 2010 |
— | — | — | Brunet Vega et al, 2013 | ||
miR-92 | Upregulated | 0.885 | 89% | 70% | Ng et al, 2009 |
miR-92a | 0.838 | 84% | 71.2% | Huang et al, 2010 | |
miR-92a-3p | 0.786 | 65.5% | 82.5% | Liu et al, 2013 | |
0.890 | — | — | Zheng et al, 2014 | ||
miR-96 | Upregulated | 0.740 | 65.4% | 73.3% | Sun et al, 2016 |
miR-106a | Upregulated | 0.605 | 74% | 44.4% | Chen et al, 2015 |
0.808 | — | — | Li et al, 2015 | ||
miR-182 | Upregulated | — | — | — | Perilli et al, 2014 |
miR-200c | Upregulated | 0.749 | 64.1% | 73.3% | Zhang et al, 2013 |
miR-206 | Upregulated | 0.705 | — | — | Xu et al, 2014 |
miR-210 | Upregulated | 0.821 | 74.6% | 73.5% | Wang et al, 2016 |
miR-221 | Upregulated | 0.606 | 86% | 41% | Pu et al, 2010 |
miR-223-3p | Upregulated | 0.871 | — | — | Zheng et al, 2014 |
miR-372 | Upregulated | 0.854 | 81.9% | 73.3% | Yu et al, 2016 |
miR-378 | Upregulated | 0.796 | — | — | Zanutto et al, 2014 |
miR-24 | Downregulated | 0.839 | 78.38% | 83.85% | Fang et al, 2015 |
miR-26a-5p | Downregulated | 0.670 | — | — | Ghanbari et al, 2015 |
miR-29b | Downregulated | 0.743 | 61.4% | 72.5% | Li et al, 2015 |
0.870 | 77% | 75% | Basati et al, 2015 | ||
miR-30b | Downregulated | — | — | — | Ho et al, 2015 |
miR-142-3p | Downregulated | 0.710 | — | — | Ghanbari et al, 2015 |
miR-145 | Downregulated | — | — | — | Ramzy et al, 2015 |
0.874 | — | — | Li et al, 2015 | ||
miR-194 | Downregulated | 0.850 | 72% | 80% | Basati et al, 2015 |
miR-218 | Downregulated | — | — | — | Yu et al, 2013 |
miR-320a | Downregulated | 0.886 | 92.79% | 73.08% | Fang et al, 2015 |
miR-375 | Downregulated | 0.749 | 76.92% | 64.63% | Xu et al, 2014 |
miR-422a | Downregulated | 0.843 | — | — | Zheng et al, 2014 |
miR-423-5p | Downregulated | 0.833 | 91.89% | 70.77% | Fang et al, 2015 |
miR-601 | Downregulated | 0.747 | 69.2% | 72.4% | Wang et al, 2012b |
miR-760 | Downregulated | 0.788 | 80% | 72.4% | Wang et al, 2012b |
Two miRNA panels | |||||
miR-19a, -19b | Upregulated | 0.820 | 78.57% | 77.36% | Giraldez et al, 2013 |
miR-21, -92a | Upregulated | 0.847 | 68% | 91.2% | Liu et al, 2013 |
miR-29a, -92a | Upregulated | 0.883 | 83% | 84.7% | Huang et al, 2010 |
miR-200c, -18a | Upregulated | 0.839 | 84.6% | 75.6% | Zhang et al, 2013 |
miR-431, -139-3p | Upregulated | 0.829 | 91% | 57% | Kanaan et al, 2013 |
miR-601, -760 | Downregulated | 0.792 | 83.3% | 69.1% | Wang et al, 2012b |
miR-375, -206 | Upregulated and Downregulatedb | 0.846 | — | — | Xu et al, 2014 |
Three miRNA panels | |||||
miR-19a, -19b, -15b | Upregulated | 0.840 | 78.57% | 79.25% | Giraldez et al, 2013 |
miR-486, -25, -1180 | Upregulated | — | — | — | Ho et al, 2015 |
miR-24, -320a, -423-5p | Downregulated | 0.899 | 92.79% | 70.77% | Fang et al, 2015 |
miR-145, -106a, -17-3p | Upregulated and Downregulated | 0.886 | 78.5% | 82.8% | Li et al, 2015 |
miR-409-3p, -7, -93 | Upregulated and Downregulated | 0.897 | 82% | 89% | Wang et al, 2015 |
Panels with ⩾4 miRNA | |||||
miR-18a, -19a, -19b, -15b, 29a, -335 | Upregulated | 0.70–0.80 | — | — | Giraldez et al, 2013 |
miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145 | Upregulated | 0.745 | — | — | Luo et al, 2013 |
miR-423-5p, -210, -720, -320a, -378, -92a, -29a, 155 | Upregulated | — | — | — | Hofsli et al, 2013 |
miR-7, -17-3p, -20a, -21, -92a, -96, -183, -196a, -214 | Upregulated | — | — | — | Ahmed et al, 2012 |
miR-29a, -92a, -601, -760 | — | 0.943 | 83.3% | 93.1% | Wang et al, 2012b |
miR-124, -127-5p, -138, -143, -146a, -222 | Downregulated | — | — | — | Ahmed et al, 2012 |
miR-106a, -143, -103, -199-3p, -151-5p, -107, -191, -423-3p, -221, -382, -409-3p, -652, let 7d | Downregulated | — | — | — | Hofsli et al, 2013 |
Abbreviations: CRC=colorectal cancer; miRNA=microRNA.
Not reported.
Upregulated and downregulated—where the individual miRNAs were either upregulated or downregulated in CRC compared with healthy controls.