Table 2. Significantly dysregulated miRNAs in the plasma and serum of patients with CRC as compared with controls.

miRNA	Expression	Area under the curve (AUC)	Sensitivity	Specificity	Study
Single miRNA
miR-17-3p	Upregulated	0.717	64%	70%	Ng et al, 2009
		0.781	—a	—	Li et al, 2015
miR-18a	Upregulated	0.804	73.1%	79.1%	Zhang et al, 2013
		—	—	—	Brunet Vega et al, 2013
miR-19a-3p	Upregulated	0.849	—	—	Zheng et al, 2014
miR-20a	Upregulated	0.590	46%	73.42%	Chen et al, 2015
miR-21	Upregulated	0.910	90%	90%	Kanaan et al, 2012
		0.850	87.5%	74.4%	Wang and Zhang, 2012
		0.802	65%	85%	Liu et al, 2013
		0.927	82.8%	90.6%	Toiyama et al, 2013
		0.870	77%	78%	Basati et al, 2014
		0.877	76.2%	93.2%	Du et al, 2014
		0.647	—	—	Zanutto et al, 2014
miR-29a	Upregulated	0.844	69%	89.1%	Huang et al, 2010
		—	—	—	Brunet Vega et al, 2013
miR-92	Upregulated	0.885	89%	70%	Ng et al, 2009
miR-92a		0.838	84%	71.2%	Huang et al, 2010
miR-92a-3p		0.786	65.5%	82.5%	Liu et al, 2013
		0.890	—	—	Zheng et al, 2014
miR-96	Upregulated	0.740	65.4%	73.3%	Sun et al, 2016
miR-106a	Upregulated	0.605	74%	44.4%	Chen et al, 2015
		0.808	—	—	Li et al, 2015
miR-182	Upregulated	—	—	—	Perilli et al, 2014
miR-200c	Upregulated	0.749	64.1%	73.3%	Zhang et al, 2013
miR-206	Upregulated	0.705	—	—	Xu et al, 2014
miR-210	Upregulated	0.821	74.6%	73.5%	Wang et al, 2016
miR-221	Upregulated	0.606	86%	41%	Pu et al, 2010
miR-223-3p	Upregulated	0.871	—	—	Zheng et al, 2014
miR-372	Upregulated	0.854	81.9%	73.3%	Yu et al, 2016
miR-378	Upregulated	0.796	—	—	Zanutto et al, 2014
miR-24	Downregulated	0.839	78.38%	83.85%	Fang et al, 2015
miR-26a-5p	Downregulated	0.670	—	—	Ghanbari et al, 2015
miR-29b	Downregulated	0.743	61.4%	72.5%	Li et al, 2015
		0.870	77%	75%	Basati et al, 2015
miR-30b	Downregulated	—	—	—	Ho et al, 2015
miR-142-3p	Downregulated	0.710	—	—	Ghanbari et al, 2015
miR-145	Downregulated	—	—	—	Ramzy et al, 2015
		0.874	—	—	Li et al, 2015
miR-194	Downregulated	0.850	72%	80%	Basati et al, 2015
miR-218	Downregulated	—	—	—	Yu et al, 2013
miR-320a	Downregulated	0.886	92.79%	73.08%	Fang et al, 2015
miR-375	Downregulated	0.749	76.92%	64.63%	Xu et al, 2014
miR-422a	Downregulated	0.843	—	—	Zheng et al, 2014
miR-423-5p	Downregulated	0.833	91.89%	70.77%	Fang et al, 2015
miR-601	Downregulated	0.747	69.2%	72.4%	Wang et al, 2012b
miR-760	Downregulated	0.788	80%	72.4%	Wang et al, 2012b
Two miRNA panels
miR-19a, -19b	Upregulated	0.820	78.57%	77.36%	Giraldez et al, 2013
miR-21, -92a	Upregulated	0.847	68%	91.2%	Liu et al, 2013
miR-29a, -92a	Upregulated	0.883	83%	84.7%	Huang et al, 2010
miR-200c, -18a	Upregulated	0.839	84.6%	75.6%	Zhang et al, 2013
miR-431, -139-3p	Upregulated	0.829	91%	57%	Kanaan et al, 2013
miR-601, -760	Downregulated	0.792	83.3%	69.1%	Wang et al, 2012b
miR-375, -206	Upregulated and Downregulatedb	0.846	—	—	Xu et al, 2014
Three miRNA panels
miR-19a, -19b, -15b	Upregulated	0.840	78.57%	79.25%	Giraldez et al, 2013
miR-486, -25, -1180	Upregulated	—	—	—	Ho et al, 2015
miR-24, -320a, -423-5p	Downregulated	0.899	92.79%	70.77%	Fang et al, 2015
miR-145, -106a, -17-3p	Upregulated and Downregulated	0.886	78.5%	82.8%	Li et al, 2015
miR-409-3p, -7, -93	Upregulated and Downregulated	0.897	82%	89%	Wang et al, 2015
Panels with ⩾4 miRNA
miR-18a, -19a, -19b, -15b, 29a, -335	Upregulated	0.70–0.80	—	—	Giraldez et al, 2013
miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145	Upregulated	0.745	—	—	Luo et al, 2013
miR-423-5p, -210, -720, -320a, -378, -92a, -29a, 155	Upregulated	—	—	—	Hofsli et al, 2013
miR-7, -17-3p, -20a, -21, -92a, -96, -183, -196a, -214	Upregulated	—	—	—	Ahmed et al, 2012
miR-29a, -92a, -601, -760	—	0.943	83.3%	93.1%	Wang et al, 2012b
miR-124, -127-5p, -138, -143, -146a, -222	Downregulated	—	—	—	Ahmed et al, 2012
miR-106a, -143, -103, -199-3p, -151-5p, -107, -191, -423-3p, -221, -382, -409-3p, -652, let 7d	Downregulated	—	—	—	Hofsli et al, 2013

Abbreviations: CRC=colorectal cancer; miRNA=microRNA.

^aNot reported.

^bUpregulated and downregulated—where the individual miRNAs were either upregulated or downregulated in CRC compared with healthy controls.