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(A) LINE-1 and (B) L1-MET methylation percentages in normal colorectal mucosa, different adenoma groups (MAP, FAP/AFAP and sporadic) and MAP cancers; the methylation threshold was set at 60% as the lowest methylation value of normal mucosa for both LINE-1 and L1-MET; black columns represent hypomethylated samples (< 60%), while grey columns identify samples with a methylation level >60%.
