Table 1.
Characteristics of study participants
| PEAR1 rs12041331 genotype | |||||
|---|---|---|---|---|---|
| Trait, units | Total | G/G | G/A | A/A | P valuea |
| Number | 67 | 34 | 28 | 5 | |
| Age ± SD, year | 50.2 ± 1.2 | 49.7 ± 1.7 | 51.6 ± 1.9 | 45.4 ± 4.6 | 0.86 |
| Sex (n = Female) (%) | 28 (42) | 15 (44) | 10 (36) | 3 (60) | 0.96 |
| BMI ± SD (kg/m2) | 28.4 ± 0.6 | 28.0 ± 0.9 | 29.1 ± 0.9 | 27.4 ± 2.2 | 0.41 |
| Hypertensionb (%) | 4 (6) | 2 (6) | 2 (7) | 0 (0) | 0.83 |
| Hypercholesterolemiac (%) | 18 (27) | 9 (26) | 9 (32) | 0 (0) | 0.6 |
| Self‐reported diabetes (%) | 0 | 0 | 0 | 0 | N/A |
| Current smoker (%) | 7 (10) | 3 (9) | 4 (14) | 0 (0) | 0.96 |
| Hematocrit ± SD (%) | 40.3 ± 0.4 | 40.3 ± 0.5 | 40.3 ± 0.6 | 39.9 ± 1.0 | 0.85 |
| White blood count ± SD (n × 1,000/μl) | 5.8 ± 0.2 | 5.5 ± 0.2 | 6.1 ± 0.3 | 5.8 ± 0.6 | 0.12 |
| Platelet count ± SD (n × 100,000/μl) | 223.1 ± 5.8 | 206.7 ± 7.3 | 243.8 ± 8.8 | 219.2 ± 20.8 | 0.03 |
A/A, minor allele homozygotes; BMI, body mass index; G/A, heterozygotes; G/G, major allele homozygotes; N/A, not applicable; PEAR1, platelet endothelial aggregation receptor 1.
a P values represent statistical difference of each trait by PEAR1 rs12041331 genotype. bDefined as systolic blood pressure greater than 140 mm Hg or diastolic blood pressure greater than 90 mm Hg or taking prescription medication for previously diagnosed hypertension. cDefined as low‐density lipoprotein cholesterol >160 mg/dL or taking prescription medication for previously diagnosed hypercholesterolemia.