Table 1.

Domains of Precision Medicine – Proposed Nomenclature

ENDOME Within the organism*	ECTOME Outside the organism
Genome ‐ genetic information Proteome ‐ proteins expressed by a genome Metabolome ‐ small‐molecule chemicals within a biological sample Transcriptome – messenger RNA molecules in a cell or population of cells Secretome – secreted organic molecules and inorganic elements by cells, tissues, and organs Translatome – messenger RNA fragments present in a cell Foldome – folded structures of proteins ORFeome – open reading frames in the genome Glycome – carbohydrates in a cell, or full complement of sugars in an organism Regulome – regulatory components in a cell	Environmental factors Aerome – air Hydrome – water Terrome – soil Nutriome – consumed food Biome – flora and fauna (including microbiota)
	Social factors Philome – family & social support network Allolome – other human beings not in the Philome Legome – educational achievement & opportunities Econome – economic circumstances Ethnome – culture, including race/ethnicity Actome – physical activity Home – living environment, including neighborhood
	Health care factors Iatrome – health care experienced by a person Therapome – therapeutic care Preventome – preventive care Pharmacome – pharmaceuticals

^*Domains within the endome are select examples previously described and named in published literature, with descriptions/definitions.