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. 2017 Mar 17;7:44758. doi: 10.1038/srep44758

Figure 7. Penetration of loaded MSCs into B16F10 tumor spheroids.

Figure 7

(A) Schematic diagram of experiment design. (B) Confocal laser scanning images of B16F10 tumor spheroids after incubated with DOX or PLGA-DOX loaded MSCs for 48 h ranging from 0–100 μm. (C) A representative image of B16F10 tumor spheroid in bright field with a spherical shape. (D) Mean fluorescence intensity calculated by Image J software at the depth of 40, 60, 80 μm. Data were presented as mean ± standard deviation, (n = 3 replicates for each group). *p < 0.05, **p < 0.01.