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. 2017 Mar 17;7:44571. doi: 10.1038/srep44571

Figure 1. Obese mice have impaired vascular reactivity.

Figure 1

Age-matched WT and HFD WT mice were analyzed for vascular reactivity and adipose tissue alterations. (a) The anti-contractile effect of PVAT observed in WT mice is lost in HFD mice (mean ± SEM from one experiment; n = 8 (WT) and 5 (HFD); P = NS, two-way ANOVA) (no PVAT (-■-) and PVAT (-□-)). (b) Representative H&E staining of mesenteric adipose tissue from control and HFD mice, and (c) analysis of adipocyte size (HFD: n = 5, and WT: n = 8; ***P < 0.0001, Student’s t-test). Scale bar shows 100 μm. (d) Mesenteric adipose tissue of HFD and control mice was analyzed for number of eosinophils (mean ± SEM; HFD: n = 5, and WT: n = 8; *P = 0.0113, Student’s t-test). (e) Representative flow cytometric plots of mesenteric adipose tissue eosinophils from control and HFD mice.