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. 2017 Mar 17;7:44824. doi: 10.1038/srep44824

Figure 2. Effects of cancer cell-derived conditioned media on osteoblast proliferation and differentiation.

Figure 2

(a) Osteoblast proliferation was significantly inhibited by osteolytic B16F10 and MDA-MB-231 conditioned media and (b) promoted by osteoblastic MDA-PCa-2b conditioned media depending on the concentration of the conditioned media. (c) Gene expression levels of ALP in osteoblasts cultured in osteolytic conditioned media were significantly downregulated compared to osteoblastic MDA-PCa-2b conditioned media. B16: B16F10, MM231: MDA-MB-231, PCa: MDA-PCa-2b.