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. 2016 Nov 29;8(2):2550–2557. doi: 10.18632/oncotarget.13707

Table 1. All 12 studies identified through database searching.

Author Included/Excluded Comments
Xie et al. 2015 [33] Excluded Norcantharidin inhibits Wnt signal pathway via promoter demethylation of WIF-1 in human NSCLC.
Xu et al. 2015 [34] Excluded Bisdemethoxycurcumin effects on TGF-β1 induced EMT in NSCLC are mediated through WIF-1
Tan et al. 2013 [32] Excluded miR-29s suppress the Wnt signaling pathway through demethylation of WIF-1 in NSCLC.
Liu et al. 2011 [35] Excluded Hypomethylation effects of curcuminoid on WIF-1 promoter in NSCLC cell lines.
Liu et al. 2011a [12] Excluded Hypomethylation agent induces apoptosis in human NSCLC
Suzuki et al. 2010 [36] Included Molecular Characterization of Chronic Obstructive Pulmonary Disease-Related NSCLC through WIF-1aberrant methylation and Alterations of EGFR Signaling.
Gao et al. 2009 [37] Excluded The role of Epigallocatechin-3- gallate in the reversal of WIF-1 promoter methylation in NSCLC cell line
Gao et al. 2009a [38] Excluded Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells
Yoshino et al. 2009 [20] Included Promoter hypermethylation of the p16 and WIF-1genes as an independent prognostic marker in stage IA NSCLC.
Yang et al. 2009 [39] Excluded The role WIF-1 promoter hypermethylation in the diagnosis of NSCLC-related malignant pleural effusion.
Ren et al. 2007 [9] Included The relationship between WIF-1, Gsk-3β and nm23-H1 expression and the prognosis in patient with non-small cell lung cancer.
Mazieres et al. 2004 [19] Included Promoter Hypermethylation in Human lung cancer.