Table 1.

Criteria used for mutation filtering (variant inclusion)

Criterion name	Threshold value
General quality
Phred-based quality	>50
Strand bias	≤0.75
Number of reads supporting called variant	≥10
Functional relevance
Variant allelic frequency	≥5%
Localization	Exonic and splice site
Variant effect	Non-synonymous
SNP exclusion
Variant allelic frequency	<95%
Database annotation and alternative allelic frequency (1000 genomes project, European descendent samples)	Not listed in dbSNP v138 or listed, but MAF ≤0.01%
Variants in detected in the control cohort of 23 non-tumoral samples from lymphoma patients	Not overlapping