Table 1.
Functional and pathway enrichment analysis of up-regulated and down-regulated genes in hepatocellular carcinoma (HCC) tissue
| Category | Term | Count | % | P Value |
|---|---|---|---|---|
| Up-regulated | ||||
| GOTERM_BP_FAT | GO:0007059 ~ chromosome segregation | 9 | 17.6 | 2.66E-06 |
| GOTERM_BP_FAT | GO:0098813 ~ nuclear chromosome segregation | 8 | 15.7 | 1.06E-05 |
| GOTERM_BP_FAT | GO:0000819 ~ sister chromatid segregation | 7 | 13.7 | 2.91E-05 |
| GOTERM_BP_FAT | GO:0051301 ~ cell division | 9 | 17.6 | 1.31E-04 |
| GOTERM_BP_FAT | GO:0007067 ~ mitotic nuclear division | 8 | 15.7 | 1.44E-04 |
| GOTERM_CC_FAT | GO:0000793 ~ condensed chromosome | 5 | 9.8 | 2.14E-03 |
| GOTERM_CC_FAT | GO:0005829 ~ cytosol | 18 | 35.3 | 3.98E-03 |
| GOTERM_CC_FAT | GO:0005578 ~ proteinaceous extracellular matrix | 5 | 9.8 | 1.51E-02 |
| GOTERM_CC_FAT | GO:0098651 ~ basement membrane collagen trimer | 2 | 3.9 | 2.08E-02 |
| GOTERM_CC_FAT | GO:0005694 ~ chromosome | 7 | 13.7 | 3.38E-02 |
| GOTERM_MF_FAT | GO:0042826 ~ histone deacetylase binding | 3 | 5.9 | 3.03E-02 |
| KEGG_PATHWAY | hsa04512:ECM-receptor interaction | 3 | 5.9 | 1.68E-02 |
| Down-regulated | ||||
| GOTERM_BP_FAT | GO:0006956 ~ complement activation | 6 | 10.0 | 1.83E-05 |
| GOTERM_BP_FAT | GO:0072376 ~ protein activation cascade | 6 | 10.0 | 6.43E-05 |
| GOTERM_BP_FAT | GO:0019752 ~ carboxylic acid metabolic process | 12 | 20.0 | 8.21E-05 |
| GOTERM_BP_FAT | GO:0043436 ~ oxoacid metabolic process | 12 | 20.0 | 8.66E-05 |
| GOTERM_BP_FAT | GO:0006955 ~ immune response | 16 | 26.7 | 1.23E-04 |
| GOTERM_CC_FAT | GO:0005581 ~ collagen trimer | 4 | 6.7 | 7.15E-03 |
| GOTERM_CC_FAT | GO:0072562 ~ blood microparticle | 4 | 6.7 | 1.91E-02 |
| GOTERM_CC_FAT | GO:0005579 ~ membrane attack complex | 2 | 3.3 | 2.67E-02 |
| GOTERM_CC_FAT | GO:0031988 ~ membrane-bounded vesicle | 21 | 35.0 | 4.60E-02 |
| GOTERM_CC_FAT | GO:0044421 ~ extracellular region part | 22 | 36.7 | 5.00E-02 |
| GOTERM_MF_FAT | GO:0005496 ~ steroid binding | 4 | 6.7 | 3.47E-03 |
| GOTERM_MF_FAT | GO:0070330 ~ aromatase activity | 3 | 5.0 | 3.57E-03 |
| GOTERM_MF_FAT | GO:0016712 ~ oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | 3 | 5.0 | 4.11E-03 |
| GOTERM_MF_FAT | GO:0004497 ~ monooxygenase activity | 4 | 6.7 | 4.77E-03 |
| GOTERM_MF_FAT | GO:0004252 ~ serine-type endopeptidase activity | 5 | 8.3 | 7.38E-03 |
| KEGG_PATHWAY | hsa05204:Chemical carcinogenesis | 6 | 10.0 | 4.53E-05 |
| KEGG_PATHWAY | hsa00140:Steroid hormone biosynthesis | 4 | 6.7 | 3.04E-03 |
| KEGG_PATHWAY | hsa00830:Retinol metabolism | 4 | 6.7 | 4.19E-03 |
| KEGG_PATHWAY | hsa00982:Drug metabolism - cytochrome P450 | 4 | 6.7 | 4.76E-03 |
Count: the number of enriched genes in each term
If there were more than five terms enriched in this category, the top five terms were selected per the P value