Fig. 5.

Context-dependent prioritization shows GWAS signal enrichment in relevant cells. a The top 5% prioritized SNPs using blood cell line Mo-CD14+ (purple) display more leftward shift than using skin (green), muscle (blue), or liver (gold) cell lines against permutated GWAS signals; gray area shows 95% intervals of permutated signals. b The top 5% prioritized SNPs using blood cell line GM12878 (red) display more leftward shift than using skin (green), muscle (blue), or liver (gold) cell lines against permutated GWAS signals; gray area shows 95% intervals of permutated signals. c The empirical P values of permutations for blood cell lines (Mo-CD14+ and GM12878) are more significant than other tissue/cell types. d After the blood cell line Mo-CD14+ prioritization, the top-ranked SNPs display more significant shift from permutated GWAS signals than lower-ranked ones; gray area shows 95% intervals of permutated signals. BLD blood, LNG lung, SKIN skin, BONE bone, LIV liver, VAS vascular, MUS muscle, BRN brain, CRVX cervix, BRST breast, Composite context-free composite model