Table 3. Summary association results of PRPF6 rs8126213 (G > A) in all of the eight lung cancer GWASs.

Study population	Sample size		Overall (N = 14463)		AD (N = 4862)		SQ (N = 3897)
	Cases	Controls	OR (95% CI)*	P*	OR (95% CI)*	P*	OR (95% CI)*	P*
TRICL	12160	16838	0.89 (0.85–0.94)	1.65E-05	0.88 (0.81–0.95)	9.0E-04	0.88 (0.82–0.96)	2.20E-03
ICR	1952	5200	0.94 (0.85–1.05)	0.303	0.94 (0.77–1.15)	0.572	0.92 (0.77–1.20)	0.374
MDACC	1150	1134	0.87 (0.73–1.04)	0.120	0.87 (0.71–1.07)	0.199	0.84 (0.64–1.11)	0.219
IARC	2533	3791	0.91 (0.81–1.01)	0.075	0.93 (0.76–1.13)	0.456	0.91 (0.78–1.06)	0.238
NCI	5713	5736	0.87 (0.81–0.95)	8.36E-04	0.86 (0.77–0.97)	0.012	0.85 (0.75–0.96)	7.92E-03
Toronto	331	499	0.86 (0.62–1.20)	0.379	0.77 (0.47–1.27)	0.314	0.97 (0.51–1.83)	0.923
GLC	481	478	0.83 (0.63–1.10)	0.195	0.67 (0.45–0.98)	0.041	1.01 (0.64–1.58)	0.979
Harvard and deCODE	2303	27350	0.98 (0.89–1.09)	0.772	0.97 (0.84–1.12)	0.683	1.02 (0.82–1.26)	0.875
Harvard	984	970	0.97 (0.79–1.20)	0.801	0.94 (0.74–1.18)	0.576	0.97 (0.68–1.40)	0.886
deCODE	1319	26380	0.99 (0.87–1.12)	0.850	0.99 (0.82–1.20)	0.940	1.04 (0.80–1.37)	0.761
All combined	14463	44188	0.91 (0.87–0.95)	6.36E-05	0.91 (0.87–0.95)	1.70E-03	0.90 (0.83–0.97)	4.80E-03

Abbreviations: TRICL: GWASs datasets combined by six GWASs of ICR, MDACC, IARC, NCI, Toronto and GLC; ICR: the Institute of Cancer Research Genome-wide Association Study, UK; MDACC: the MD Anderson Cancer Center Genome-wide Association Study, US; IARC: the International Agency for Research on Cancer Genome-wide Association Study, France; NCI: the National Cancer Institute Genome-wide Association Study, US; Toronto: the Lunenfeld-Tanenbaum Research Institute Genome-wide Association Study, Toronto, Canada; GLC: German Lung Cancer Study, Germany; Harvard: Harvard Lung Cancer Study, US; deCODE: Icelandic Lung Cancer Study, Iceland; AD: adenocarcinoma; SQ: squamous cell carcinoma; ^*Meta-analysis of results from additive model.