Table 2.
Comparison of aortic dimension and WSS between MFS groups and healthy subjects
| Group 1 MFS - pDAo Z ≥ 2.0 (n = 7) |
Group 2 MFS - pDAo Z < 2.0 (n = 18) |
Group 3 Healthy subjects (n = 21) |
|
|---|---|---|---|
| Age (y) | 15.6 ± 4.5 | 15.6 ± 4.0 | 16.0 ± 2.6 |
| Females (n) | 3 | 8 | 12 |
| BSA (m2) | 1.6 ± 0.4 | 1.8 ± 0.3 | 1.6 ± 0.3 |
| Thoracic aortic size (Z-score) | |||
| Z-score Aortic Root** | 4.4 ± 1.3 | 3.2 ± 1.4 | 0.5 ± 0.8 |
| Z-score STJ** | 3.0 ± 0.9 | 1.2 ± 1.0 | −0.3 ± 0.8 |
| Z-score AAo** | 1.1 ± 0.7 | −0.1 ± 0.8 | −0.5 ± 0.6 |
| Z-score distal Arch* | 0.8 ± 0.7 | −0.1 ± 0.9 | −0.2 ± 0.7 |
| Z-score Isthmus** | 2.0 ± 0.7 | 0.6 ± 0.7 | 0.4 ± 0.5 |
| Z-score proximal DAo** | 4.2 ± 1.1 | 1.2 ± 0.6 | 0.6 ± 0.7 |
| Δ diameter Root-AAo (%)** | 30.9 ± 4.0 | 33.8 ± 7.0 | 19.0 ± 7.0 |
| Δ diameter Isthmus-pDAo (%)** | 27.9 ± 9.1 | 10.4 ± 10.1 | 1.9 ± 5.7 |
| WSSmean (Pa) | |||
| 1. Inner pAAo* | 0.69 ± 0.18 | 0.81 ± 0.09 | 0.86 ± 0.16 |
| 2. Outer pAAo | 0.59 ± 0.11 | 0.67 ± 0.11 | 0.73 ± 0.14 |
| 3. Inner dAAo* | 0.85 ± 0.18 | 0.97 ± 0.11 | 0.85 ± 0.15 |
| 4. Outer dAAo | 0.75 ± 0.14 | 0.87 ± 0.11 | 0.83 ± 0.14 |
| 5. Inner Arch | 0.83 ± 0.13 | 0.99 ± 0.13 | 0.91 ± 0.16 |
| 6. Outer Arch | 0.71 ± 0.09 | 0.80 ± 0.11 | 0.79 ± 0.14 |
| 7. Inner pDAo* | 0.58 ± 0.13 | 0.80 ± 0.14 | 0.87 ± 0.21 |
| 8. Outer pDAo | 0.76 ± 0.13 | 0.89 ± 0.10 | 0.86 ± 0.12 |
| 9. Inner dDAo | 0.75 ± 0.09 | 0.89 ± 0.16 | 0.89 ± 0.17 |
| 10. Outer dDAo* | 0.78 ± 0.05 | 0.99 ± 0.18 | 0.97 ± 0.16 |
Significant across subgroups using a Kruskal-Wallis test. *p < 0.05, **p < 0.001. Abbreviations: pAAo proximal ascending aorta, dAAo distal ascending aorta, Arch aortic arch, pDAo proximal descending aorta, dDAo distal descending aorta