Fig. 5.

Coronin-1C is a downstream target of YB-1. a Gene expression of CORO1C upon silencing of YBX1 or CORO1C. b Gene expression of YBX1 upon silencing of YBX1 or CORO1C. c Representative images of Western blot showing the expression of coronin-1C and YB-1 proteins. There is a decrease in CORO1C gene or protein expression upon silencing of CORO1C or YBX1 when compared to siNeg cells in MDA-MB-231 cell line. In contrast, YBX1 gene and protein expression were decreased in siYB-1 MDA-MB-231 cells only, indicating that coronin-1C is a likely downstream target of YB-1. Error bar = SEM, *p < 0.05, **p < 0.01, ***p < 0.001, indicates statistically significant difference