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. 2017 Feb 22;7(2):170001. doi: 10.1098/rsob.170001

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — Uneven distribution of Pol III on transcription units. (a) Pol III distribution pattern, identified by CRAC method, across most genes, with a high peak of nascent transcript density over the 5′-end of the transcription unit and a weaker peak before the 3′-end of mature tRNA (intron-less tRNA gene is shown). Read-through (RT) of termination signal is observed on many tRNA genes, typically extending 50–200 nt beyond the expected canonical termination site. (b) Localization of A- and B-boxes of the bipartite internal promoter, and termination site (T_n) in a tRNA-encoding gene (tDNA). (c) The τA and τB modules of TFIIIC factor binding the A- and B-boxes. Regions of postulated transient pausing of Pol III correspond to the TFIIIC binding sites.