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Table 1.

Patient characteristics

PD, n = 15 Non-PD, n = 69 P*
Age, median (range), y 65 (56-79) 68 (33-85) .39
Sex, n (%) .99
 Male 9 (60.0) 40 (58.0)
 Female 6 (40.0) 29 (42.0)
Rai stage, n (%) .36
 Rai I/II 3 (20.0) 24 (34.8)
 Rai III/IV 12 (80.0) 45 (65.2)
FISH, n (%) .04
 Deletion 13q 0 (0.0) 10 (14.5)
 Normal 0 (0.0) 1 (1.4)
 Trisomy 12 2 (13.3) 7 (10.1)
 Deletion 11q 0 (0.0) 11 (15.9)
 Deletion 17p 13 (86.7) 40 (58.0)
IGHV, n (%) .24
 Mutated 3 (20.0) 26 (37.7)
 Unmutated 12 (80.0) 43 (62.3)
B2M
 Median (range)§ 5.7 (1.8-10.3) 3.6 (1.7-12.9) .005
 >4 mg/L, n (%) 13 (86.7) 27 (39.1) .001
 >3.5 mg/L, n (%) 13 (86.7) 35 (50.7) .02
Prior treatment, n (%) .003
 Treatment-naive 4 (26.7) 48 (69.6)
 Relapsed/refractory 11 (73.3) 21 (30.4)
*

The Fisher exact test and the Wilcoxon rank-sum test were used to compare categorical variables and continuous variables between patients who progressed (PD) and those who did not (non-PD).

Hierarchical FISH categories.

The Fisher exact test in subgroups divided by the presence or the absence of deletion 17p.

§

The median B2M for all patients was 4 mg/L.