Table 1.
Patient characteristics
| PD, n = 15 | Non-PD, n = 69 | P* | |
|---|---|---|---|
| Age, median (range), y | 65 (56-79) | 68 (33-85) | .39 |
| Sex, n (%) | .99 | ||
| Male | 9 (60.0) | 40 (58.0) | |
| Female | 6 (40.0) | 29 (42.0) | |
| Rai stage, n (%) | .36 | ||
| Rai I/II | 3 (20.0) | 24 (34.8) | |
| Rai III/IV | 12 (80.0) | 45 (65.2) | |
| FISH, n (%)† | .04‡ | ||
| Deletion 13q | 0 (0.0) | 10 (14.5) | |
| Normal | 0 (0.0) | 1 (1.4) | |
| Trisomy 12 | 2 (13.3) | 7 (10.1) | |
| Deletion 11q | 0 (0.0) | 11 (15.9) | |
| Deletion 17p | 13 (86.7) | 40 (58.0) | |
| IGHV, n (%) | .24 | ||
| Mutated | 3 (20.0) | 26 (37.7) | |
| Unmutated | 12 (80.0) | 43 (62.3) | |
| B2M | |||
| Median (range)§ | 5.7 (1.8-10.3) | 3.6 (1.7-12.9) | .005 |
| >4 mg/L, n (%) | 13 (86.7) | 27 (39.1) | .001 |
| >3.5 mg/L, n (%) | 13 (86.7) | 35 (50.7) | .02 |
| Prior treatment, n (%) | .003 | ||
| Treatment-naive | 4 (26.7) | 48 (69.6) | |
| Relapsed/refractory | 11 (73.3) | 21 (30.4) |
*
The Fisher exact test and the Wilcoxon rank-sum test were used to compare categorical variables and continuous variables between patients who progressed (PD) and those who did not (non-PD).
†
Hierarchical FISH categories.
‡
The Fisher exact test in subgroups divided by the presence or the absence of deletion 17p.
§
The median B2M for all patients was 4 mg/L.