Table 2.

Vasoactive medications commonly used in CDH: Typical doses, route of administration of inotropic and vasodilator medications in the management of CDH

Drug	Route	Units	Initial dose	Maintenance Dose range
DOPAmine	IV	μg/kg/min	1 to 5	1 to 50 (usually 2.5 to 20)
DOBUTamine	IV	μg/kg/min	1 to 5	1 to 40 (usually 2.5 to 20)
EPInephrine	IV	μg/kg/min	0.05 to 0.1	0.1 to 1
NOREPInephrine	IV	μg/kg/min	0.05 to 0.1	0.05 to 2
PGE1 – Alprostadil	IV	μg/kg/min	0.05 to 0.1	0.01 to 4
PGE1 – Alprostadil	Inhaled	μg/kg/min	0.15 to 0.3	0.15 to 0.3
Milrinone	IV	μg/kg/min	0.25 to 0.75 (some units use a load of 50 μg/kg)	0.25 to 1
Dexamethasone	IV	mg/kg/dose	0.05 to 0.6	0.05 to 0.6
Hydrocortisone	IV	mg/kg/dose	1 to 5	0.5 to 5
Nitric oxide (NO)	Inhaled	Ppm	5 to 20	1 to 80
Vasopressin	IV	Units/kg/min	0.0001 to 0.002	0.0001 to 0.008
Prostacyclin (Epoprostenol - Flolan)	IV	ng/kg/min	1 to 3	50 to 80
Prostacyclin (Epoprostenol - Flolan)	Inhaled	ng/kg/min	50	25 to 50
Prostacyclin (Treprostinil – Remodulin)	SQ or IV	ng/kg/min	1.25 to 2	50 to 80
Prostacyclin (Treprostinil – Remodulin)	Inhaled	μg/breath	6
Prostacyclin (Iloprost)	Inhaled	μg/breath	2.5 or 5
Prostacyclin (Beraprost)	PO	μg	80	80 to 120 (adult dose)
Sildenafil	IV	mg/kg/h	0.14 for 3 h	0.07
Bosentan	PO	mg/kg/dose	1 to 2	1 to 2