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. 2017 Mar 15;5:e3078. doi: 10.7717/peerj.3078

Figure 3. The transcription factors-target genes regulatory network of top 10 up and down-regulated DEGs in synovial tissues of RA.

Figure 3

Transcription factors can regulate gene expression through binding to the promoter regions of target genes. The white and grey rectangle nodes represented up- and down-regulated DEGs, respectively. The ellipse nodes represented transcription factors. Solid lines represented regulatory correlation between transcription factors and DEGs. For instance, NSA2 was down-regulated in synovial tissues of RA and its expression level can be regulated by six transcription factors including CP2, COMP1,Nkx2-5, OCT1, Pax4 and HNF-1 based on TRANSFAC database prediction.