Figure 1. Serum HE4 is strongly associated with progression of CKD in patients.
A. Differential levels of serum HE4 in patients with CKD or NC (normal healthy control) group. Results indicated that serum HE4 levels were elevated in patients with CKD, and increased with a higher stage of CKD (*P < 0.0001). B. Differential levels of serum HE4 for male patients. Serum HE4 levels are elevated in male patients with CKD (*P < 0.0001). C. Differential levels of serum HE4 for female patients. Serum HE4 levels are elevated in female patients with CKD (*P < 0.0001). D. Receiver-operating characteristic curve analysis displaying the diagnostic power in predicting disease severity of CKD in patients by serum HE4 levels (area under the curve, AUC: 0.981).