Table 2. Association between HE4 levels and characteristical variables in CKD patients/normal controls.

	Number	HE4 (pmol/L)	Pvalues
Combined
Controls	173	35.4 (30.9-42.9)	<0.0001
CKD	427	329.0 (146.1-750.2)
Controls
Men	79	35.7 (30.6-41.3)	0.2683
Women	94	37.8 (32.8-43.9)
CKD
Men	222	346.8 (152.0-972.2)	0.3740
Women	205	325.0 (137.3-626.2)
Men
Controls
<50 (Y)	62	34.1 (30.4-38.6)	0.0011
≥50 (Y)	17	49.5 (41.3-68.3)
CKD
<50 (Y)	167	294.0 (141.8-747.4)	0.0413
≥50 (Y)	55	579.0 (213.0-1393.8)
Women
Controls
Premenopausal	71	35.2 (31.3-39.7)	<0.0001
Postmenopausal	23	50.0 (41.0-59.8)
CKD
Premenopausal	164	283.9 (121.0-622.0)	0.0921
Postmenopausal	41	360.9 (297.7-634.3)

The association between HE4 levels and characteristical variables were analyzed by Mann-Whitney U-test.