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. 2016 Sep 8;7(42):67760–67776. doi: 10.18632/oncotarget.11917

Figure 3. Enhanced elastin degradation in angiotensin II-infused HO-1−/−apoE−/− mice.

Figure 3

HO-1+/+apoE−/− A.-C. and HO-1−/−apoE−/− D.-L. mice were infused with angiotensin II for 4 weeks and abdominal aortas harvested for histological analysis. H&E A. and D. and Verhoeff's elastin staining B.-C. and E.-L. of mouse AAA sections. C. and F. Higher magnification of the boxed areas in B. and E., respectively. H. and I. Higher magnification of the boxed areas in G. K. Higher magnification of the boxed area in J. Arrows indicate disrupted elastin fibers. T, thrombus. L. A ruptured AAA. M. Quantitative analysis of elastin degradation grade from HO-1+/+apoE−/− mice infused with saline (n = 4) or angiotensin II (n = 13) and HO-1−/−apoE−/− mice infused with saline (n = 5) or angiotensin II (n = 13). *P < 0.05 vs. HO-1+/+apoE−/− mice.