Figure 2. Characterization of different breast cancer PDXs.

A. The expression of the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 were evaluated in samples from the indicated patient (hu, human) and the corresponding PDX (mo, mouse). B. Unsupervised hierarchical clustering of the samples from the original tumor (hu) or samples from the corresponding PDXs (mo) according to the levels of expression of 110 selected genes analyzed using the Counter platform. All tumors were assigned to an intrinsic molecular type of breast cancer (Luminal A, Luminal B, HER2-enriched, and Basal-like) [26]. The analyses of PDXs 154, 67 and 50 and PDXs 243 and 377 are presented separately because they were performed in different experiments. C. Results of analyses performed as in A and B on the indicated PDXs. Note that the characterization of PDX118 has been published elsewhere [16].