Table 3. Genotypic model analysis of relationship between SNPs and steroid-induced ONFH risk.
Model | Genotype | Group = control | Group = Hormone | Without Adjustment | With Adjustment | ||
---|---|---|---|---|---|---|---|
OR (95% CI) | pa-value | OR (95% CI) | pa-value | ||||
Codominant | G/G | 364 (71.8%) | 226 (79.3%) | 1 | 1 | ||
G/T | 133 (26.2%) | 55 (19.3%) | 0.67 (0.47–0.95) | 0.063 | 0.69 (0.48–1.00) | 0.100 | |
T/T | 10 (2%) | 4 (1.4%) | 0.64 (0.20–2.08) | 0.56 (0.17–1.92) | |||
Dominant | G/G | 364 (71.8%) | 226 (79.3%) | 1 | 1 | ||
0.019* | 0.034* | ||||||
G/T-T/T | 143 (28.2%) | 59 (20.7%) | 0.66 (0.47–0.94) | 0.68 (0.47–0.98) | |||
Recessive | G/G-G/T | 497 (98%) | 281 (98.6%) | 1 | 1 | ||
0.550 | 0.420 | ||||||
T/T | 10 (2%) | 4 (1.4%) | 0.71 (0.22–2.28) | 0.61 (0.18–2.08) | |||
Overdominant | G/G-T/T | 374 (73.8%) | 230 (80.7%) | 1 | 1 | ||
0.026* | 0.055 | ||||||
G/T | 133 (26.2%) | 55 (19.3%) | 0.67 (0.47–0.96) | 0.70 (0.48–1.01) | |||
Log-additive | — | — | — | 0.70 (0.51–0.96) | 0.022* | 0.70 (0.51–0.98) | 0.033* |
p ≤ 0.05.
Bonferroni's multiple adjustment was applied to the level of significance, which was set at p ≤ 0.00104 (0.05/48).
p values were calculated by Wald test by unconditional logistic regression adjusted for age and gender.