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. 2016 Sep 15;7(42):68434–68441. doi: 10.18632/oncotarget.12034

Table 3. Genotypic model analysis of relationship between SNPs and steroid-induced ONFH risk.

Model Genotype Group = control Group = Hormone Without Adjustment With Adjustment
OR (95% CI) pa-value OR (95% CI) pa-value
Codominant G/G 364 (71.8%) 226 (79.3%) 1 1
G/T 133 (26.2%) 55 (19.3%) 0.67 (0.47–0.95) 0.063 0.69 (0.48–1.00) 0.100
T/T 10 (2%) 4 (1.4%) 0.64 (0.20–2.08) 0.56 (0.17–1.92)
Dominant G/G 364 (71.8%) 226 (79.3%) 1 1
0.019* 0.034*
G/T-T/T 143 (28.2%) 59 (20.7%) 0.66 (0.47–0.94) 0.68 (0.47–0.98)
Recessive G/G-G/T 497 (98%) 281 (98.6%) 1 1
0.550 0.420
T/T 10 (2%) 4 (1.4%) 0.71 (0.22–2.28) 0.61 (0.18–2.08)
Overdominant G/G-T/T 374 (73.8%) 230 (80.7%) 1 1
0.026* 0.055
G/T 133 (26.2%) 55 (19.3%) 0.67 (0.47–0.96) 0.70 (0.48–1.01)
Log-additive 0.70 (0.51–0.96) 0.022* 0.70 (0.51–0.98) 0.033*
*

p ≤ 0.05.

Bonferroni's multiple adjustment was applied to the level of significance, which was set at p ≤ 0.00104 (0.05/48).

p values were calculated by Wald test by unconditional logistic regression adjusted for age and gender.