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. 2016 Sep 9;7(42):68674–68687. doi: 10.18632/oncotarget.11919

Figure 5. Expression level of LASP1 inversely correlates with miR-145 level in vitro, in vivo and in CRC patients' tissue specimens.

Figure 5

A, B. Expression levels of LASP1 in matched (normal mucosa) primary tumor and metastatic tumor tissues from 33 CRC patients as detected by qRT-PCR analyses (A) and IHC staining (B, from No. 5 of the 33 patients). * P < 0.05 (Paired t-test). Scale bars are 100 μm. C. Expression levels of miR-145 and LASP1 in Hct116, Ht29, LoVo, Sw480 and Sw620 cells were detected by qRT-PCR. Data represent the mean ± s.e.m. of three independent experiments. D. Representative photographs of anti-LASP1 IHC staining of lung (upper) or liver (lower) metastatic tumor tissues from Sw620/Lenti-NC and Sw620/Lenti-miR-145 nude mice groups. Scale bars are 50 μm. E. The correlation of LASP1 mRNA and miR-145 in metastatic tumor tissues from 33 CRC patients. The Pearson product-moment correlation coefficient and significance level are indicated.