Figure 8. Expression of NLGN4Y in PC-3 leads to changes in cell morphology, cell motility and small Rho GTPase activities.
A and B. NLGN4Y expression induced prolonged membrane blebbing stage during attachment to culture vessel. C. NLGN4Y expression caused changes in small Rho GTPase activities. D. NLGN4Y expression induced abnormal F-actin organization as shown by phalloidin-rhodamine staining. E. NLGN4Y expression significantly decreased cell migration in a transwell migration assay using serum as a chemo-attractant. *: p<0.05; **: p<0.01 and ***: p<0.001.