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. 2016 Sep 8;7(42):68749–68767. doi: 10.18632/oncotarget.11899

Figure 10. Effects of PDGF on tumor cell signaling, and metabolism.

Figure 10

PDGF decreases apoptosis, and increases glycolysis and proliferation in an Akt-dependent manner in CRC. It also activates HIF1α, and C-Myc, and suppresses Rb to accelerate metabolism and the proliferative potential of PDGF. This stimulating mechanisms highlight the importance and the potential of the PDGF-PI3K/Akt/mTOR pathway-axis as a possible target in colorectal cancer. PDGF, platelet-derived growth factor; PI3K, phosphoinositide 3-kinase; mTOR, target of Rapamycin; HIF1α, hypoxia-inducible-factor 1α; Rb, Retinoblastoma; GLUT1, glucose transporter 1; LDHA, lactate dehydrogenase A; MCT4, monocarboxylate transporter 4.