Table 1. The basic characteristic of the enrolled subjects.
| Variable | HCC (n=63) | LC (n=87) | CHB (n=86) | HCs (n=30) | P-value |
|---|---|---|---|---|---|
| Male (%) | 47 (74.6) | 65 (74.7) | 49 (72.1) | 16 (53.3) | 0.133a |
| Age (years) | 59 (52-62) | 58 (50-63) | 59 (53-64) | 55 (45-61) | 0.160b |
| HBsAg (IU/mL) | 4887 (134-6598) | 5175 (972-6819) | 2157 (838-5661) | NA | 0.252b |
| HBeAg+(%) | 22 (34.9) | 58 (66.7) | 50 (73.5) | NA | <0.001a |
| HBV DNA+(%) | 27 (42.9) | 61 (70.1) | 54 (79.4) | NA | <0.001a |
| WBC (109/L) | 6.01 (4.72-8.23) | 5.23 (3.43-6.98) | 5.35 (4.52-6.23) | NA | 0.050b |
| HGB (g/L) | 134 (118-145) | 132 (114-141) | 147 (138-153) | NA | <0.001b |
| PLT (109/L) | 149 (100-243) | 103 (82-145) | 197 (156-230) | NA | <0.001b |
| ALT (U/L) | 56 (38-139) | 52 (35-93) | 120 (51-263) | NA | <0.001b |
| AST (U/L) | 57 (40-88) | 54 (31-70) | 55 (35-123) | NA | 0.181b |
| ALB (g/L) | 35.9 (32.8-39.9) | 32.7 (29.4-38.8) | 41.4 (37.7-44.8) | NA | <0.001b |
| TBIL (umol/L) | 33.1 (16.5-52.2) | 27.9 (17-58) | 38.1 (16.4-94.7) | NA | 0.754b |
| PTA (%) | 74 (62-82) | 70 (55-81) | 97 (90-105) | NA | <0.001b |
| PT-INR | 1.13 (1.07-1.24) | 1.17 (1.03-1.34) | 0.99 (0.94-1.04) | NA | <0.001b |
| Cr (umol/L) | 67 (57-74) | 63 (55-80) | 60 (50-68) | NA | 0.010b |
| MELD score | 6.52 (5.07-9.30) | 6.99 (4.32-11.65) | NA | NA | 0.702c |
| AFP (ng/mL) | 70.8 (15.3-242) | 14.2 (4.2-38.1) | 10.5 (5.0-34.7) | NA | <0.001b |
| Ascites (%) | 21 (33.3) | 33 (37.9) | NA | NA | 0.267a |
| HE (%) | 13 (20.6) | 12 (13.8) | NA | NA | 0.563a |
| Variceal bleeding (%) | 28 (44.4) | 23 (26.4) | NA | NA | 0.022a |
Quantitative variables were expressed as the median (centile 25; centile 75).
Categorical variables were expressed as number (%).
a
Chi-square test;
b
Kruskal-Wallis test;
c
Mann-Whitney U test.
HCC, hepatocellular carcinoma; LC, liver cirrhosis; CHB, chronic hepatitis B; HCs, healthy controls; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; WBC, white blood cell; HGB, haemoglobin; PLT, platelet; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; TBIL, total bilirubin; PTA, prothrombin time activity; PT-INR, prothrombin time-international normalized ratio; Cr, creatinine; MELD = model for end-stage liver disease; AFP, alpha-fetoprotein; HE = hepatic encephalopathy; NA, not available.