Table 3. The efficacy (overall survival and progression-free survival) of eight drugs in chemotherapy of glioblastoma followed by surgery and radiotherapy according to the network meta-analysis using hazard ratio (HR) and corresponding 95% credible intervals (CrIs).
| Endpoints | OS | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| PFS | Placebo | 1.47 (1.25, 1.73) | 1.23 (0.98, 1.55) | 1.67 (1.34, 2.08) | 1.47 (0.90, 2.39) | 1.63 (1.27, 2.10) | 2.83 (1.29, 6.21) | 1.30 (0.94, 1.79) | 1.23 (0.96, 1.58) |
| 0.63 (0.54, 0.73) | TMZ | 0.84 (0.64, 1.11) | 1.14 (0.98, 1.32) | 1.00 (0.60, 1.67) | 1.11 (0.91, 1.35) | 1.92 (0.89, 4.15) | 0.88 (0.62, 1.26) | 0.84 (0.62, 1.13) | |
| 0.65 (0.53, 0.80) | 1.03 (0.80, 1.34) | PCV | 1.35 (0.99, 1.86) | 1.19 (0.70, 2.04) | 1.32 (0.94, 1.85) | 2.29 (1.01, 5.20) | 1.05 (0.71, 1.56) | 1.00 (0.90, 1.11) | |
| 0.40 (0.32, 0.50) | 0.64 (0.55, 0.75) | 0.62 (0.46, 0.84) | BEV+TMZ | 0.88 (0.52, 1.50) | 0.97 (0.76, 1.24) | 1.69 (0.77, 3.71) | 0.78 (0.53, 1.14) | 0.74 (0.53, 1.03) | |
| 0.75 (0.49, 1.15) | 1.19 (0.75, 1.88) | 1.15 (0.71, 1.86) | 1.86 (1.15, 3.02) | Nimotuzumab | 1.11 (0.64, 1.92) | 1.92 (0.76, 4.85) | 0.88 (0.49, 1.58) | 0.84 (0.49, 1.45) | |
| 0.57 (0.45, 0.71) | 0.90 (0.76, 1.06) | 0.87 (0.64, 1.18) | 1.41 (1.12, 1.77) | 0.76 (0.47, 1.23) | Cilengitide+TMZ | 1.74 (0.78, 3.84) | 0.80 (0.53, 1.20) | 0.76 (0.53, 1.08) | |
| 0.56 (0.30, 1.05) | 0.89 (0.48, 1.63) | 0.86 (0.44, 1.66) | 1.39 (0.74, 2.61) | 0.75 (0.35, 1.60) | 0.99 (0.53, 1.85) | TMZ+ACNU+CDDP | 0.46 (0.20, 1.07) | 0.44 (0.19, 1.00) | |
| 0.75 (0.57, 0.98) | 1.19 (0.87, 1.62) | 1.15 (0.81, 1.62) | 1.86 (1.31, 2.64) | 1.00 (0.60, 1.67) | 1.32 (0.93, 1.88) | 1.34 (0.68, 2.65) | DBD+BCNU | 0.95 (0.63, 1.42) | |
| 0.65 (0.52, 0.82) | 1.03 (0.78, 1.36) | 1.00 (0.91, 1.10) | 1.62 (1.18, 2.23) | 0.87 (0.53, 1.42) | 1.15 (0.83, 1.59) | 1.17 (0.60, 2.27) | 0.87 (0.61, 1.25) | DMFO+PCV | |