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. 2004 Dec 1;32(21):6218–6225. doi: 10.1093/nar/gkh944

Figure 1.

Figure 1

The origin of Ad5 DNA replication. The Ad5 origin consists of a highly conserved core origin with the pTP/pol binding site and an auxiliary origin containing the consensus sequences recognised by the NFI and Oct-1 (boxed). The arrows indicate the middle of the NFI consensus sequence at position 31 and the middle of the Oct-1 recognition sequence between position 43 and 44. The binding half-sites for the POUs and POUh are indicated. The ATGA sequence (in bold) within the Oct-1 binding site represents the apparent centre of DNA bending induced by Oct-1 as demonstrated by biochemical assays (37).