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| Code | 5′-Sequence-2′/3′b | IC50 (μM) |
|---|---|---|
| RRR | GGAC(UUCG)GUCC | 25.8 |
| ARU | AAAC(UUCG)GUUU | — |
| R1RR1 | UCGC(UUCG)GCGA | — |
| R2RR2 | GAGC(UUCG)GCUC | 28.5 |
| R3RR3 | GCAC(UUCG)GUGC | 43.4 |
IC50 is the oligomer concentration required to inhibit 50% RNase H activity of HIV-1 RT. Capital letters represent RNA residues. Measurements for the inhibition assay were repeated twice and were run in the same way as described in Materials and Methods section.
