Figure 7. Suppression function of COX-2 in the U87 xenograft model does indeed lead to less vascular mimicry.

Thedensity of PAS+/CD34- structures in control tumors were about 2.9-fold greater than those found in celecoxib-treated tumors (11.0% vs. 3.8%, p = 0.0124). In VM positive area (A, arrow), the COX-2 staining reaction was much stronger (B) than those in VM-negative area (C, D).