Table 1. Detailed list of the 56 protein coding genes presenting with differential CNVs distribution between ER and LR.
| Chr. Band |
Gene | Gene full name | Description/function |
|---|---|---|---|
| 1p21 | AMY2A | Amylase, Alpha 2A | Member of the alpha-amylase family |
| 1q44 | HNRPU | Heterogeneous Nuclear Ribonucleoprotein U | pre-mRNA processing |
| 1q44 | OR2T34 | Olfactory receptor, family 2, subfam. T, mb 34 | G-protein-coupled olfactory receptor |
| 1q44 | OR2AK2 | Olfactory receptor, family 2, subfam. AK, mb 2 | G-protein-coupled olfactory receptor |
| 2p11 | IGKV3D-7 | Immunoglobulin kappa variable 3D-7 | BCR assembly |
| 2q24 | GALNT5 | N-Acetylgalactosaminyltransferase 5 | O-linked oligosaccharide biosynthesis |
| 2q31 | NFE2L2 | Nuclear factor (erythroid-derived 2)-like 2 | Transcriptionnal regulator |
| 2q33 | SNORA1 | Small nucleolar RNA, H/ACA box 1 | Novel snoRNA/Small nucleolar RNA |
| 2q37 | MTERF4 | Mitochondrial Transcription Termination Factor 4 | Regulator of mitochondrial gene expression |
| 2q37 | UBE2F-SCLY | UBE2F-SCLY Readthrough | MHC class I mediated antigen processing |
| 2q37 | C2orf82 | Chromosome 2 Open Reading Frame 82 | --- |
| 3q22 | PRR23B | Proline Rich 23B | --- |
| 3q25 | AADAC | Arylacetamide deacetylase | Microsomal arylacetamide deacetylase |
| 3q27 | DVL3 | Dishevelled, dsh homolog 3 | Regulation of cell proliferation |
| 3q29 | CPN2 | Carboxypeptidase N, Polypeptide 2 | Carboxypeptidase |
| 3q29 | SENP5 | SUMO1/sentrin specific peptidase 5 | Post-translational modification of proteins |
| 3q29 | MUC20 | Mucin 20, Cell Surface Associated | Glycoprotein of mucous barrier |
| 3q29 | HES1 | Hairy enhancer of split 1 | Transcription factor |
| 6p21 | CSNK2B/CK2B | Casein kinase 2, beta subunit | Regulation of programmed cell death |
| 6p21 | BTNL2 | Butyrophilin-Like 2 | Negative regulation of T-cell proliferation |
| 6p21 | CCHCR1 | Coiled-Coil Alpha-Helical Rod Protein 1 | Regulation of keratinocyte proliferation |
| 6p21 | HIST1H1T | Histone Cluster 1, H1t | Epigenetic regulation of transcription |
| 6p21 | HLA-DRA | MHC complex, Class II, DR Alpha | Antigen presentation |
| 6p22 | HIST1H2BC | Histone Cluster 1, H2bc | Epigenetic regulation of transcription |
| 6p22 | HIS1H2AK | Histone Cluster 1, H2ak | Epigenetic regulation of transcription |
| 6p22 | KAAG1 | Kidney Associated Antigen 1 | --- |
| 6p25 | SERPINB1 | Serpin Peptidase Inhibitor, Class B , Mb1 | Proteinase inhibition |
| 6q13 | KHDC1 | KH homology domain containing 1 | Predicted membrane protein |
| 7p22 | GPR146 | G Protein-Coupled Receptor 146 | G protein coupled receptor |
| 7q11 | ABHD11 | Abhydrolase domain containing 11 | --- |
| 7q11 | STX1A | Syntaxin 1A | Docking of synaptic vesicles |
| 11p15 | ART5 | ADP-Ribosyltransferase 5 | ARG-specific ADP-ribosyltransferase |
| 12p13 | PRH1 | Proline-Rich Protein HaeIII Subfamily 1 | Inhibition of crystal calcium phosphates |
| 12p13 | C1R | Complement Component 1, R Subcomponent | Complement activation |
| 12p13 | PTMS | Parathymosin | Inhibition of linkage of H1 to chromatin |
| 12q24 | DIABLO | Diablo, IAP-Binding Mitochondrial Protein | Apoptosis promotion |
| 12q24 | LRRC43 | Leucine Rich Repeat Containing 43 | --- |
| 13q13 | EXOSC8 | Exosome Component 8 | Transcriptionnal regulation |
| 14q11 | OR4Q3 | Olfactory receptor, family 4, subfam. Q, mb 3 | G-protein-coupled olfactory receptor |
| 14q11 | TRAV-26-1 | T Cell Receptor Alpha Variable 26-1 | TCR assembly |
| 14q11 | TRAJ10 | T Cell Receptor Alpha Joining 10 | TCR assembly |
| 14q11 | TRAJ13 | T Cell Receptor Alpha Joining 13 | TCR assembly |
| 14q12 | RP11-468E2.6 | --- | --- |
| 14q32 | IGHVIII-2-1 | Immunoglobulin Heavy Variable (III)-2-1 | BCR assembly |
| 14q32 | IGHVIII-16-1 | Immunoglobulin Heavy Variable (III)-16-1 | BCR assembly |
| 14q32 | DCAF11 | DDB1 And CUL4 Associated Factor 11 | Assembly of the DDB1–CUL4A ubiquitin ligase |
| 15q15 | CATSPER2 | Cation Channel, Sperm Associated 2 | Sperm motility and male fertility |
| 16p13 | NARFL | Nuclear prelamin A recognition factor-like | Modulation of hypoxia-inducible factor-1α activity |
| 16q22 | HAS3 | Hyaluronan Synthase 3 | Synthesis of glycosaminoglycan hyaluronan |
| 16q22 | CDH16 | Cadherin 16 | Ca2+-dependent glycoprotein |
| 16q22 | CLEC18B | C-Type Lectin Domain Family 18, Member B | --- |
| 17p11 | LGALS9C | Lectin, Galactoside-Binding, Soluble, 9C | Regulation of immune response |
| 19p13 | LRG1 | Leucine-rich alpha-2-glycoprotein 1 | Signal transduction, and cell adhesion |
| 19p13 | ZNF414 | Zinc Finger Protein 414 | Transcriptional regulation |
| 19p13 | AC008686.1 | --- | Uncharacterized protein |
| 22q13 | ADSL | Adenylosuccinate lyase | De novo purine biosynthesis |
The SAM method allowed identification of 148 genes with differentially distributed genomic alterations between ER and LR DLBCLs. The 56 protein coding genes are presented in this table.