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. 2016 Aug 22;7(51):84003–84016. doi: 10.18632/oncotarget.11510

Figure 6. Methylation patterns of tumors in each patient.

Figure 6

Case-1A and Case-2 showed single epigenotype in all the tumors. Case-1B, Case-1C, and Case-3 showed two distinct epigenotypes in a single patient. Case-1A, Case-1B and Case-1C were from the same family and possessed the same APC germline mutation (L540X). Nevertheless, Case-1B and Case-1C showed two epigenotypes and Case-1A showed low-methylation epigenotype only throughout the colon. For Case-3, intermediate-methylation tumors were preferentially observed with KRAS mutation (P = 0.03) and in the proximal colon (P = 0.009). For Case-1B, a significant association was observed between intermediate-methylation epigenotype and proximal location (P = 0.007).