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. 2016 Nov 16;7(51):84054–84071. doi: 10.18632/oncotarget.13414

Figure 7. PI3Kβ depletion selectively impairs N-cadherin-mediated cell adhesions.

Figure 7

a. 639V, J82 and SW780 cells were transfected with control or siPIK3CB1 shRNA or cultured with 250 nM AZD8186 (72 h). Cells were stained with the indicated antibodies and examined by confocal microscopy (indicated). Representative z-sections are shown. Quantitation of N-cad or β-cat signal in arbitrary units (AU) in the linear plots (indicated). b. Percentage of 639V, J82, RT112 and SW780 cells with normal cell adhesions defined as those showing N-cad (or E-cad) and β-cat colocalization in the membrane region between adjacent cells in at least in one side of the cell. *** P < 0.001, * P < 0.05; Student's t-test.