Figure 3.

Average number of FDRs in CHIEFc enzyme families versus the average pairwise sequence identity of their corresponding homofunctional MSAs. The FDRs are selected based on the conservation score of either homofunctional MSAs alone (closed circles and open circles, to discriminate four EC digits and the first three EC digits, respectively), or both homofunctional MSAs and heterofunctional MSAs (closed triangles and open triangles, to discriminate four EC digits and the first three EC digits, respectively).