Figure 4. Effect of RSV and MET alone or combination treatment on tumor growth in xenografts model.

Miapaca-2 cells were injected subcutaneously into the flanks of nude mice. Drug administration was maintained for 40 days, and then mice were sacrificed. Tumor growth curves (A), tumor volume (B), tumor weight (C) and mice body weight (D) on day 40 were presented. Graphs represent mean ± SEM (CON group: n = 6, other three groups: n = 8). ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. CON group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. RSV group; ^$p < 0.05, ^$$p < 0.01, ^$$$p < 0.001 vs. MET group.