Figure 5. Effect of RSV and MET alone or combination treatment on VEGF-B signaling pathway and tumor apoptosis in xenografts model.

The expression of VEGF-B (A), phosphorylated GSK-3β (B), phosphorylated Akt (C), Bax and Bcl-2 (D), and cleaved-caspase3 (E) were presented. Graphs represent mean ± SEM (CON group: n = 6, other three groups: n = 8). ^*p < 0.05, ^**p < 0.01 vs. CON group; ^#p < 0.05 vs. RSV group; ^$p < 0.05 vs. MET group.